pretty sound)
"1.The microorganism must be found in abundance in all organisms suffering
from the disease, but should not be found in healthy animals.
2.The microorganism must be isolated from a diseased organism and grown in
pure culture.
3.The cultured microorganism should cause disease when introduced into a
healthy organism.
4.The microorganism must be reisolated from the inoculated, diseased
experimental host and identified as being identical to the original specific
causative agent.
Koch's postulates were developed in the 19th century as general guidelines
to identify pathogens that could be isolated with the techniques of the
day.[3] Even in Koch's time, it was recognized that some infectious agents
were clearly responsible for disease even though they did not fulfill all of
the postulates.[2][4] Attempts to rigidly apply Koch's postulates to the
diagnosis of viral diseases in the late 19th century, at a time when viruses
could not be seen or isolated in culture, may have impeded the early
development of the field of virology.[5][6] Currently, a number of
infectious agents are accepted as the cause of disease despite their not
fulfilling all of Koch's postulates.[7] Therefore, while Koch's postulates
retain historical importance and continue to inform the approach to
microbiologic diagnosis, fulfillment of all four postulates is not required
to demonstrate causality."
Jean Harrison
"The terrain is everything" att'd to Pasteur
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