ith Chronic Fatigue Syndrome
Journal: Science [Published on-line as a Sciencexpess Report: October 8, =
2009]
Authors: Vincent C. Lombardi [1*], Francis W. Ruscetti [2*],=20
Jaydip Das Gupta [3], Max A. Pfost [1], Kathryn S. Hagen [1],
Daniel L. Peterson [1],Sandra K. Ruscetti [4], Rachel K. Bagni [5],
Cari Petrow-Sadowski [6], Bert Gold [2], Michael Dean [2] Robert=20
H. Silverman [3], Judy A. Mikovits [1=86]
Affiliations:
[1] Whittemore Peterson Institute, Reno, NV 89557, USA.
=20
[2] Laboratory of Experimental Immunology, National Cancer=20
Institute-Frederick, Frederick, MD 21701, USA.=20
[3] Department of Cancer Biology, The Lerner Research Institute, The=20
Cleveland Clinic Foundation, Cleveland, OH 44106, USA.
=20
[4] Laboratory of Cancer Prevention, National Cancer=20
Institute-Frederick, Frederick, MD 21701, USA.=20
[5] Advanced Technology Program, National Cancer Institute-
Frederick, Frederick, MD 21701, USA.=20
[6] Basic Research Program, Scientific Applications International=20
Corporation, National Cancer Institute-Frederick, Frederick, MD 21701, US=
A.
*These authors contributed equally to this work.
=86To whom correspondence should be addressed. E-mail: <judym@wpinstitute=
.org>
Abstract:
Chronic fatigue syndrome (CFS) is a debilitating disease
of unknown etiology that is estimated to affect 17 million
people worldwide. Studying peripheral blood
mononuclear cells (PBMCs) from CFS patients, we
identified DNA from a human gammaretrovirus,
xenotropic murine leukemia virus-related virus (XMRV),
in 68 of 101 patients (67%) compared to 8 of 218 (3.7%)
healthy controls. Cell culture experiments revealed that
patient-derived XMRV is infectious and that both cellassociated
and cell-free transmission of the virus are
possible. Secondary viral infections were established in
uninfected primary lymphocytes and indicator cell lines
following exposure to activated PBMCs, B cells, T cells, or
plasma derived from CFS patients. These findings raise
the possibility that XMRV may be a contributing factor in
the pathogenesis of CFS.
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