----------
Brain Res Bull. 2011 Jul 28. [Epub ahead of print]
Epigallocatechin gallate ameliorates behavioral and biochemical
deficits in rat model of load-induced chronic fatigue syndrome.
Sachdeva AK, Kuhad A, Chopra K.
Source
Pharmacology Research Laboratory, University Institute of
Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab
University, Chandigarh 160 014, India.
Abstract
Chronic fatigue syndrome is a heterogeneous disorder with unknown
pathogenesis and etiology, characterized by tiredness, difficulty in
concentration and memory, and concomitant skeletal and muscular pain,
thus affecting both mental and physical domains. The pathogenesis of
chronic fatigue syndrome is multifactorial and involves increased
oxido-nitrosative stress along with generation of pro-inflammatory
cytokines such as TNF-=CE=B1. In the present study chronic fatigue was
produced in rats by plunging a load of 10=C2=B12% body weight and
subjecting them to forced swim inside a rectangular jar daily for 28
days. Endurance capacity and post-swim fatigue were assessed on 1st,
7th, 14th, 21st and 28th days. EGCG was administered daily by oral
gavage 30min before forced swim session. On the 29th day, after
assessment of various behavioral parameters, blood was collected
through tail vein, and animals were sacrificed to harvest the brains,
spleens and thymus. Chronic fatigue group exhibited significant
behavioral alterations along with enhanced oxido-nitrosative stress
and serum TNF-=CE=B1 level as compared to naive group. Chronic treatment
with EGCG restored all the behavioral and biochemical alterations
associated with chronic fatigue syndrome. The present study signifies
the therapeutic potential of EGCG for the treatment of chronic fatigue
syndrome.
Copyright =C2=A9 2011 Elsevier Inc. All rights reserved.
PMID:
21821105
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21821105
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