Multiple Slcerosis. =20
http://www.webmd.com/multiple-sclerosis/glatiramer-acetate-for-multiple-s=
clerosis=20
http://www.rxlist.com/copaxone-drug/clinical-pharmacology.htm=20
A Th2 shift is known to occur in ME/CFS (at least for a large subset).=20
~jw
______________
Glatiramer acetate reverts stress-induced alterations on adult =
neurogenesis and behavior. Involvement of Th1/Th2 balance.
Mar=EDa Laura Palumbo (a),=20
Mariela Fernanda Trinchero (b),=20
Mar=EDa Aurelia Zorrilla-Zubilete (a),=20
Alejandro Fabi=E1n Schinder (b),=20
Ana Mar=EDa Genaro (a) (corresponding author)
(a) CEFYBO-CONICET, 1=AA. C=E1tedra de Farmacolog=EDa, Facultad de =
Medicina, UBA, Buenos Aires, Argentina
(b) Laboratorio de Plasticidad Neuronal, Instituto Leloir-CONICET, =
Buenos Aires, Argentina
Received 15 September 2011. Revised 11 December 2011. Accepted 12 =
December 2011. Available online 17 December 2011.
Abstract
Long-term exposure to stressful situations has deleterious effects on =
adult neurogenesis, behavior, and the immune system. We have previously =
shown that stressed BALB/c mice show poor learning performance, which =
correlates with an increase in the T helper 1/T helper 2 (Th1/Th2) =
cytokine balance. Glatiramer acetate (GA) can stimulate autoreactive T =
cells.=20
In this work we investigated the effects of GA treatment on BALB/c mice =
exposed to chronic mild stress (CMS). Stressed mice exhibited a =
significant decline in their performance in the open field and Y-maze =
tasks, which was accompanied by a reduction in dentate gyrus =
neurogenesis and an altered Th1/Th2 balance.=20
Interestingly, after 6 weeks of CMS exposure administration of GA =
reestablished normal levels of adult neurogenesis, restored the Th1/Th2 =
balance, and improved learning performance.=20
These results demonstrate that GA treatment can reverse the learning =
impairment induced by stress through a mechanism that likely involves =
the regulation of the cytokine balance and adult neurogenesis.
http://dx.doi.org/10.1016/j.bbi.2011.12.006
http://www.sciencedirect.com/science/article/pii/S0889159111006076
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