Immunoglobulin M and Immunoglobulin G Seronegative Q Fever: A
Hypothesis for Veterans? Medically Unexplained Chronic Multi-symptom
Illnesses.
Chagaris MJ, Smith RC, Goldstein AL.
Abstract
We present Q fever as a credible hypothesis for Gulf War Veterans?
Illnesses (GWVIs) and as a possible etiology for prevalent
symptomologies affecting currently serving servicemembers.
Q fever is caused by the bacteria Coxiella burnetii, which is endemic
throughout the Middle East. Q fever may manifest in many forms of
widely varying and often inconstant symptoms. Due to false-negative
interpretations in current and past diagnostic testing, Q fever has
not received appropriate consideration as a possible causative agent
for medically unexplained veterans? illnesses.
Review of current literature invites us to consider that a form of Q
fever involving an incomplete immune response is a potential cause of
these debilitating illnesses.
We hypothesize C. burnetii infection coincidental to exposures
suppressing antibody-specific immune response results in infection
mediated by immunoglobulin D (IgD). Literature indicates that
successful treatment for this form of Q fever requires the concurrent
administration of doxycycline and hydroxychloroquine.
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