J Infect Dis. 2011 Sep 29. [Epub ahead of print]
Peripheral Blood Gene Expression in Postinfective Fatigue Syndrome
Following From Three Different Triggering Infections.
Galbraith S, Cameron B, Li H, Lau D, Vollmer-Conna U, Lloyd AR.
SourceSchool of Mathematics and Statistics, Faculty of Science.
Abstract
Background.=E2=80=83Several infections trigger postinfective fatigue
syndromes, which share key illness characteristics with each other and
with chronic fatigue syndrome (CFS). Previous cross-sectional
case-control studies of CFS have suggested that unique gene expression
signatures are evident in peripheral blood samples.Methods.=E2=80=83Periphe=
ral
blood transcriptomes in samples collected longitudinally, in 18
subjects with a fatigue syndrome lasting =E2=89=A56 months after acute
infection due to Epstein-Barr virus, Ross River virus, or Coxiella
burnetii (Q fever), and 18 matched control subjects who had recovered
promptly, were studied by microarray (n =3D 127) and confirmatory
quantitative polymerase chain reaction (PCR). Gene expression patterns
associated with CFS were sought by univariate statistics and
regression modeling.Results.=E2=80=83There were 23 genes with modest
differential expression (0.6-2.3-fold change) in within-subject
comparisons of early, symptomatic time points with late, recovered
time points. There were modest differences found in 63 genes, either
in cross-sectional comparison of cases and controls at 6 months after
infection onset or in the regression model. There were 223 genes
significantly correlated with individual symptom domains. Quantitative
PCR confirmed 33 (73%) of 45 genes-none were consistent across
cohorts.Conclusions.=E2=80=83Although the illness characteristics of patien=
ts
with postinfective fatigue syndromes have more similarities than
differences, no reliable peripheral blood gene expression correlate is
evident.
PMID:21964398[PubMed - as supplied by publisher]
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