http://www.ncbi.nlm.nih.gov/pubmed/21996139
Am J Cardiol. 2011 Oct 12. [Epub ahead of print]
Relation Between Serum 25-Hydroxyvitamin D and C-Reactive Protein in Asym=
ptomatic Adults (From the Continuous National Health and Nutrition Examin=
ation Survey 2001 to 2006).
Amer M, Qayyum R.SourceJohns Hopkins University School of Medicine, Balti=
more, Maryland.
Abstract
The inverse relation between vitamin D supplementation and inflammatory b=
iomarkers among asymptomatic adults is not settled. We hypothesized that =
the inverse relation is present only at lower levels and disappears at hi=
gher serum levels of vitamin D. We examined the relation between 25-hydro=
xyvitamin D [25(OH)D] and C-reactive protein (CRP) using the continuous N=
ational Health and Nutrition Examination Survey data from 2001 to 2006. L=
inear spline [single knot at median serum levels of 25(OH)D] regression m=
odels were used. The median serum 25(OH)D and CRP level was 21 ng/ml (int=
erquartile range 15 to 27) and 0.21 mg/dl (interquartile range 0.08 to 0.=
5), respectively. On univariate linear regression analysis, CRP decreased=
[geometric mean CRP change 0.285 mg/dl for each 10-ng/ml change in 25(OH=
)D, 95% confidence interval [CI] -0.33 to -0.23] as 25(OH)D increased =E2=
=89=A421 ng/ml. However, an increase in 25(OH)D to >21 ng/ml was not asso=
ciated with any significant decrease [geometric mean CRP change 0.05 mg/d=
l for each 10-ng/ml change in 25(OH)D, 95% CI -0.11 to 0.005) in CRP. The=
inverse relation between 25(OH)D below its median and CRP remained signi=
ficant [geometric mean CRP change 0.11 mg/dl for each 10-ng/ml change in =
25(OH)D, 95% CI 0.16 to -0.04] on multivariate linear regression analysis=
. Additionally, we observed a positive relation between 25(OH)D above its=
median and CRP [geometric mean CRP change 0.06 mg/dl for each 10-ng/ml c=
hange in 25(OH)D, 95% CI 0.02 to 0.11) after adjusting for traditional ca=
rdiovascular risk factors. In conclusion, from this cohort of asymptomati=
c adults, independent of traditional cardiovascular risk factors, we obse=
rved a statistically significant inverse relation between 25(OH)D at leve=
ls <21 ng/ml and CRP. We found that 25(OH)D at a level =E2=89=A521 ng/ml =
is associated with an increase in serum CRP. It is possible that the role=
of vitamin D supplementation to reduce inflammation is beneficial only a=
mong those with a lower serum 25(OH)D.
Copyright =C2=A9 2011 Elsevier Inc. All rights reserved.
PMID: 21996139 [PubMed - as supplied by publisher]=20
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