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>>>>> Help ME Circle <<<<
>>>> 18 December 2009 <<<<
Editorship : j.van.roijen@chello.nl
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Funding Biomedical
Research into ME
Invest in ME
me solutions
Two charities are joining forces to fund research into
ME/CFS.
ME Solutions and Invest in ME are working together
to maximise the opportunities to fund research into
ME/CFS. The research project is:
The role of XMRV in modulation of
NK cell cytotoxicity and NK cell gene
abnormalities in ME/CFS patients and
normal blood donors
The project will be carried out by Dr Jonathan Kerr
and his team from St. George's University, London,
and Dr Amolak Bansal of the Department of
Immunology, Epsom & St Helier University Hospitals
NHS Trust.
Background to the project
A newly discovered y-retrovirus, Xenotropic Murine
Leukaemia Virus - like virus (XMRV) has recently
been found to be present in the blood of 68 of 101
(67%) ME/CFS patients as compared with 8 of 218
(3.7%) normal healthy controls (Lombardi et al,
2009).
XMRV has been cultured from T, B and NK cells, but
primarily targets NK cells. NK cell dysfunction has
previously been found to be abnormal in ME/CFS,
despite their numbers often being largely unaffected.
Defects in the innate immune system are thought to
play a key role in the pathogenesis of ME/CFS and
these abnormalities may leave individuals
susceptible to XMRV infection.
This study will relate the presence of XMRV in NK
cells with ME/CFS-associated abnormalities
previously demonstrated in NK cells and
ME/CFS-associated gene abnormalities.
Plan of Investigation
A sample of clinically-diagnosed (according to the
Fukuda and Canadian criteria) ME/CFS patients and
age-and-sex matched normal controls will be
recruited.
XMRV status will be determined and NK cells
obtained and tested for ME/CFS-associated gene
abnormalities in NK cells. XMRV status will be
related to ME/CFS gene expression changes.
Donations
ME Solutions and Invest in ME welcome sponsorship
and donations for this two year project which we
hope will begin as soon as possible.
The links below will allow online donations to be
made.
every click:
https://charities.everyclick.com/purchase?d=D&cn=Invest-in-ME&cid=275467&ctId=1114035&cy=GBP
JustGiving:
http://www.justgiving.com/mesolutions/donate
For further information about making
donations to this project please contact:
ME Solutions:
info@mesolutions.org.uk?subject=Biomedical%20research%20into%20ME
or
Invest in ME
info@investinme.org?subject=Biomedical%20Research%20into%20ME
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