Induced by Poly I:C in Mice.
Evid Based Complement Alternat Med.. [Epub ahead of print]
Sheng R, Xu X, Tang Q, Bian D, Li Y, Qian C, He X, Gao X, Pan R, Wang C, Luo
Y, Xia Y, Dai Y.
Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical
University, 24 Tong Jia Xiang Road, Nanjing 210009, China,
yuedaicpu@hotmail.com.
(TK: One paragraph so added a gap add the end of each sentence)
Radix Pseudostellariae is used as a tonic drug in traditional Chinese
medicine with immunomodulating and anti-fatigue activities, and the
polysaccharide is considered as the main active component.
The purpose of this study is to examine the effect of the polysaccharide
isolated from Radix Pseudostellariae (PRP) on mouse chronic fatigue syndrome
(CFS) induced by intraperitoneal injection of
polyriboinosinic:polyribocytidylic acid (poly I:C), a double-stranded
synthetic RNA.
It has shown that the fatigue symptom of mice lasted at least 1 week as
evaluated by forced swimming time.
PRP (100, 200, 400 mg kg(-1)), orally administered 3 days before poly I:C
injection, showed dose-dependent anti-fatigue effects.
In addition, poly I:C led to evident alternations in neuroendocrine and
immune systems of mice, such as reduced spontaneous activity and learning
ability, declined serum level of corticosterone, increased weight indexes
and T lymphocyte numbers in thymuses and spleens, and increased
CD4(+)/CD8(+) ratio but decreased proliferation ability of T lymphocytes in
spleens.
PRP alleviated the abnormalities caused by poly I:C, and restored the
function of hosts to normal conditions.
The findings suggest that PRP is beneficial to CFS, and the underlying
mechanisms of action involve neuroendocrine and immune systems.
PMID: 20008077 [PubMed - as supplied by publisher]
Full free text at:
http://ecam.oxfordjournals.org/cgi/content/full/nep208v1
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