J Intern Med. 2011 Nov 24. doi: 10.1111/j.1365-2796.2011.02488.x. [Epub a=
head of print]
Chronic fatigue syndrome: acute infection and history of physical activit=
y affect resting levels and response to exercise of plasma oxidant/antiox=
idant status and heat shock proteins.
Jammes Y, Steinberg JG, Delliaux S.
Source
UMR MD2 P2COE, Faculty of Medicine, Aix-Marseille University and Clinical=
Respiratory Physiology and Exercise Testing Laboratory, Thorax Pole, Nat=
ional Assistance - Hospitals in Marseille, 13915 Marseille, France.
Abstract
Objectives:=E2=80=82 A history of high-level physical activity and/or acu=
te infection might constitute stress factors affecting the plasma oxidant=
-antioxidant status and levels of heat shock proteins (HSPs) in patients =
with chronic fatigue syndrome (CFS). Design:=E2=80=82 This case-control s=
tudy compared data from 43 CFS patients to results from a matched control=
group of 23 healthy sedentary subjects. Setting and subjects:=E2=80=82 F=
ive patients had no relevant previous history (group I). Eighteen had pra=
ctised high-level sport (group II) and severe acute infection had been di=
agnosed in nine patients (group III). A combination of sport practice and=
infection was noted in 11 patients (group IV). Interventions:=E2=80=82 A=
fter examination at rest, all subjects performed a maximal cycling exerci=
se test. Plasma levels of two markers of oxidative stress [thiobarbituric=
acid reactive substances (TBARS) and reduced ascorbic acid (RAA)] and bo=
th HSP27 and HSP70 were measured. Results:=E2=80=82 At rest, compared to =
the control group, the TBARS level was higher in groups II, III and IV pa=
tients, and the RAA level was lower in groups III and IV. In addition, HS=
P70 levels were significantly lower in all CFS groups, compared with cont=
rols, but negative correlations were found between resting HSP27 and HSP7=
0 levels and the history of physical activity. After exercise, the peak l=
evel of TBARS significantly increased in groups II, III and IV, and the v=
ariations in HSP27 and HSP70 were attenuated or suppressed, with the grea=
test effects in groups III and IV. Conclusion:=E2=80=82 The presence of s=
tress factors in the history of CFS patients is associated with severe ox=
idative stress and the suppression of protective HSP27 and HSP70 response=
s to exercise.
Copyright =C2=A9 2011 The Association for the Publication of the Journal =
of Internal Medicine.
PMID: 22112145 [PubMed - as supplied by publisher]=20
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