Leukocyte Antigen Class II Alleles in Chronic Fatigue Syndrome.
Journal: Ann N Y Acad Sci. 2009 Sep;1173:589-99.
Authors: Ortega-Hernandez OD, Cuccia M, Bozzini S, Bassi N,
Moscavitch S, Diaz-Gallo LM, Blank M, Agmon-Levin N, Shoenfeld Y.
Affiliation: Department of Medicine "B" and Center for Autoimmune
Diseases, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv
University, Tel Aviv, Israel.
NLM Citation: PMID: 19758204
This study aimed to determine the influence of autoantibodies,
polymorphisms in the serotonin pathway, and human leukocyte antigen
(HLA) class II genes on age at chronic fatigue syndrome (CFS) onset
and symptoms.
Eighty-one CFS patients were enrolled, and clinical data were
recorded. Autoantibodies to different components of the central
nervous system were tested. Polymorphisms in the promoter of the
serotonin transporter gene (l/s) and a single nucleotide polymorphism
in the serotonin receptor-2A gene (A/G) as well as HLA class II
alleles were determined. Multivariate logistic-regression analyses
were carried out.
The mean age at CFS onset +/- SD was 33.5 +/- 12.5 years. An age at
CFS onset (ACFSO) during the third decade of life was associated with
the serotonin receptor AA genotype and the HLA-DRB1*03 allele. An
ACFSO during the fourth decade of life was associated with the
HLA-DRB1*07 allele, whereas an ACFSO >/= 43 years was associated with
having at least one copy of the serotonin G allele. Concerning CFS
symptoms, the serotonin AG genotype was protective against depressive
symptoms. Although having at least one copy of the serotonin A allele
and being female were associated with risk for arthralgia, the
presence of antineuronal cell antibodies was protective against this.
Episodes of unexplained fever were associated with the HLA-DRB1*11
allele. None of the genetic or serological features was associated
with myalgia. None of the antibodies determined correlated with any
ACFSO or other symptoms.
Our results reveal that in CFS, like other autoimmune diseases,
different genetic features are related to age at CFS onset and symptoms.
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