Journal: Ann N Y Acad Sci. 2009 Sep;1173:384-90.
Authors: Blaney GP, Albert PJ, Proal AD.
Affiliation: Stillpoint Centre, Vancouver, British Columbia, Canada.
<gregblaney@shaw.ca>
NLM Citation: PMID: 19758177
Recent research has implicated vitamin D deficiency (serum levels of
25-hydroxyvitamin D <50 nmol/L) with a number of chronic conditions,
including autoimmune conditions such as multiple sclerosis, lupus,
and psoriasis, and chronic conditions such as osteoporosis,
osteoarthritis, metabolic syndrome, fibromyalgia and chronic fatigue syndrome.
It has been assumed that low levels of 25-hydroxyvitamin D (25-D)
accurately indicate vitamin D storage and vitamin D receptor
(VDR)-mediated control of calcium metabolism and innate immunity. To
evaluate this assumption, 25-D and 1,25-dihydroxyvitamin D3 (1,25-D)
levels were measured in 100 Canadian patients with these conditions.
Additionally, other inflammatory markers (CK, CRP) were measured.
Results showed a strong positive association between these autoimmune
conditions and levels of 1,25-D >110 pmol/L. However, there was
little association with vitamin D deficiency or the other
inflammatory markers, meaning that the results challenge the
assumption that serum levels of 25-D are a sensitive measure of the
autoimmune disease state. Rather, these findings support the use of
1,25-D as a clinical marker in autoimmune conditions.
High levels of 1,25-D may result when dysregulation of the VDR by
bacterial ligands prevents the receptor from expressing enzymes
necessary to keep 1,25-D in a normal range.
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