Kathy and Alan Light in which they reported that-
=E2=80=A271% of the ME/CFS group (34 of 48) had increased expression of 4
genes dealing with sensory and adrenergic receptors and cytokines for
48 hours after exercise;
=E2=80=A2Those with the largest change in genetic expression also had the
largest increase in post-exercise symptoms;
=E2=80=A2The other 29% of the ME/CFS group (14 of 48) did not show the abov=
e
changes but did have a decrease in expression of the adrenergic =CE=B1-2A
receptor;
=E2=80=A2This group had significantly more orthostatic intolerance (dizzine=
ss
upon standing) than the first group;
---------------------------------------------------------------------------=
---
http://www.ncbi.nlm.nih.gov/m/pubmed/22130180/
Autoantibody activation of beta-adrenergic and muscarinic receptors
contributes to an "autoimmune" orthostatic hypotension.
Yu X, Stavrakis S, Hill MA, Huang S, Reim S, Li H, Khan M, Hamlett S,
Cunningham MW, Kem DC.
JournalJ Am Soc Hypertens. 2011 Nov 29. [Epub ahead of print]
AffiliationHeart Rhythm Institute, University of Oklahoma Health
Sciences Center and VA Medical Center, Oklahoma City, OK;
Endocrinology and the Harold Hamm Diabetes Center, Department of
Medicine, University of Oklahoma Health Sciences Center and VA Medical
Center, Oklahoma City, OK.
Abstract
BACKGROUND: Orthostatic hypotension (OH) is characterized by an
abnormal autonomic response to upright posture. Activating
autoantibodies to =CE=B21/2-adrenergic (AA=CE=B21/2AR) and M2/3 muscarinic
receptors (AAM2/3R) produce vasodilative changes in the vasculature
that may contribute to OH.
METHODS: Immunoglobulin (Ig)G from 6 patients with idiopathic OH
harboring autoantibodies and from 10 healthy control subjects were
examined for: 1) =CE=B21AR and M2R activity with a perfused Purkinje fiber
assay and PKA assay in H9c2 cells and 2) vasodilator =CE=B22AR and M3R
activity using a pressurized cremaster resistance arteriole assay.
Changes in IgG activity with and without propranolol, atropine, and
L-NAME were used to estimate AA=CE=B2AR, AAM2R, and AAM3R activation of
their respective functions.
RESULTS: All six patients had elevated enzyme-linked immunosorbent
assay titers to at least one of the receptors compared with controls.
=CE=B2AR-mediated contractility activity and M2R activity were increased in
five of the six patients. IgG from all six patients produced a direct
vasodilator effect on cremaster arterioles. =CE=B2AR and nitric oxide
synthase blockade led to near normalization of IgG-induced
vasodilation.
CONCLUSION: AA=CE=B21/2AR and AAM2/3R are present in some patients with
idiopathic OH compatible with an in vivo effect. These autoantibodies
and their cardiovascular effects provide new mechanistic insights into
the pathophysiology of OH.
Copyright =C2=A9 2011 American Society of Hypertension. Published by
Elsevier Inc. All rights reserved.
PMID22130180 [PubMed - as supplied by publisher]
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