Interleukin-8 is often associated with inflammation. The fact that
Interleukin-8 secretion is increased by oxidant stress and conversely,
Interleukin-8, by causing recruitment of inflammatory cells induces a
further increase in oxidant stress mediators, makes it a key parameter
in localized inflammation. On the other hand, The interleukin-1beta
cytokine is an important mediator of the inflammatory response, and is
involved in a variety of cellular activities, including cell
proliferation, differentiation, and apoptosis. The induction of
cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous
system (CNS) is found to contribute to inflammatory pain
hypersensitivity.
Glial cells, sometimes called neuroglia or simply glia (Greek =CE=B3=CE=BB=
=CE=AF=CE=B1,
=CE=B3=CE=BB=CE=BF=CE=AF=CE=B1 "glue"; pronounced in English either /gli=CB=
=90=C9=99/ or /gla=C9=AA=C9=99/), are
non-neuronal cells that maintain homeostasis, form myelin, and provide
support and protection for neurons in the brain, and for neurons in
other parts of the nervous system such as in the autonomous nervous
system. Activated microglial cells have been implicated in a number of
neurological disorders. Microglial cells are one of the few
residential immune cell types found in the brain. The critical
importance of microglial cells has only begun to be recognized in
immune responses to brain injury, infections, tumor, and autoimmune
disease.
J Neuroimmunol. 2011 Nov 27. [Epub ahead of print]
Evidence of central inflammation in fibromyalgia - Increased
cerebrospinal fluid interleukin-8 levels.
Kadetoff D, Lampa J, Westman M, Andersson M, Kosek E.
Osher Center for Integrative Medicine, Department of Clinical
Neuroscience, Karolinska Institute, Stockholm, Sweden.
Abstract
Activation of glia cells resulting in intrathecal elevation of
cytokines and chemokines has been hypothesized in chronic pain
syndromes such as fibromyalgia. To our knowledge, this is the first
study assessing intrathecal concentrations of pro-inflammatory
substances in fibromyalgia.
We report elevated cerebrospinal fluid and serum concentrations of
interleukin-8, but not interleukin-1beta, in FM patients.
This profile is in accordance with FM symptoms being mediated by
sympathetic activity rather than dependent on prostaglandin associated
mechanisms and supports the hypothesis of glia cell activation in
response to pain mechanisms.
Copyright =C2=A9 2011. Published by Elsevier B.V.
PMID: 22126705 [PubMed - as supplied by publisher]
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