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>>>>> Help ME Circle <<<<
>>>> 7 December 2011 <<<<
Editorship : j.van.roijen@chello.nl
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The Cheney Clinic
Changing status of XMRV / HGRV research
December 5th, 2011,
published in Public Relations
There is still no consensus in either direction for the
existence or non-existence of XMRV associated with CFS
cases.
Studies out of Europe (Belgium and Germany) and the US
(Cornell) as well as elsewhere which are separate from
WPI, FDA and NCI are demonstrating evidence that
cannot be due to a mouse contaminant for XMRV
association with CFS.
The strongest supportive study to date was reported by Dr.
David Strayer out of Hemispherex Inc, (Philadephia, PA)
at IACFS/ME in Ottawa and showed that 7/8 CFS cases
and 2/17 controls were positive for XMRV using Next
Generation Sequencing (NGS) technology available at
Roche Labs in Germany.
NGS is not susceptible to mouse contamination and
demonstrates that XMRV is in fact integrated into human
DNA which means it is a human virus.
The Science (Lombardi et al, 2009) study still stands as
the best evidence that this virus is transmissible from cell
to cell and the studies out of WPI and Belgium
demonstrate an immune response (antibodies) to XMRV
and a cytokine profile (WPI) that suggests it is pathologic.
I expect that Next Generation Sequencing or NGS, which
does not have the flaws of PCR technology in evaluating a
poorly understood human virus(es), will be the best way
forward to a consensus as to the question of association
of CFS with XMRV/HGRV.
This preliminary report out of Germany using NGS as well
as human immune response data supports the
association of XMRV with CFS, despite the flaws exposed
in the current primary PCR technology used to define this
scientific debate which appears very messy and
excessively bio-political to date.
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