Dr. Lipkin as the senior author) can be found here:
http://www.jneurovirol.com/pdf/5(5)/495-499.pdf
Mol Psychiatry. 2012 Jan 31. doi: 10.1038/mp.2011.179. [Epub ahead of print]
Absence of evidence for bornavirus infection in schizophrenia, bipolar
disorder and major depressive disorder.
Hornig M, Briese T, Licinio J, Khabbaz RF, Altshuler LL, Potkin SG,
Schwemmle M, Siemetzki U, Mintz J, Honkavuori K, Kraemer HC, Egan MF,
Whybrow PC, Bunney WE, Lipkin WI.
Source
1] Center for Infection and Immunity, Columbia University Mailman
School of Public Health, New York, NY, USA [2] Department of
Epidemiology, Columbia University Mailman School of Public Health, New
York, NY, USA.
Abstract
In 1983, reports of antibodies in subjects with major depressive
disorder (MDD) to an as-yet uncharacterized infectious agent
associated with meningoencephalitis in horses and sheep led to
molecular cloning of the genome of a novel, negative-stranded
neurotropic virus, Borna disease virus (BDV). This advance has enabled
the development of new diagnostic assays, including in situ
hybridization, PCR and serology based on recombinant proteins. Since
these assays were first implemented in 1990, more than 80 studies have
reported an association between BDV and a wide range of human
illnesses that include MDD, bipolar disorder (BD), schizophrenia (SZ),
anxiety disorder, chronic fatigue syndrome, multiple sclerosis,
amyotrophic lateral sclerosis, dementia and glioblastoma multiforme.
However, to date there has been no blinded case-control study of the
epidemiology of BDV infection.
Here, in a United States-based, multi-center, yoked case-control study
with standardized methods for clinical assessment and blinded
serological and molecular analysis, we report the absence of
association of psychiatric illness with antibodies to BDV or with BDV
nucleic acids in serially collected serum and white blood cell samples
from 396 subjects, a study population comprised of 198 matched pairs
of patients and healthy controls (52 SZ/control pairs, 66 BD/control
pairs and 80 MDD/control pairs).
Our results argue strongly against a role for BDV in the pathogenesis
of these psychiatric disorders.Molecular Psychiatry advance online
publication, 31 January 2012; doi:10.1038/mp.2011.179.
PMID: 22290118 [PubMed - as supplied by publisher]
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