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>>>> 9 February 2012 <<<<
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PubMed
US National Library of Medicine
National Institutes of Health
Adv Virol. 2011;2011:341294. Epub 2011 Sep 4.
Phylogeny-directed search for murine
leukemia virus-like retroviruses in vertebrate
genomes and in patients suffering from
myalgic encephalomyelitis/chronic fatigue
syndrome and prostate cancer.
Blomberg J, Sheikholvaezin A, Elfaitouri A,
Blomberg F, Sj=F6sten A, Mattson Ulfstedt J,
Pipkorn R, K=E4llander C, Ohrmalm C, Sperber G.
Section of Clinical Microbiology, Department of Medical
Sciences, Uppsala University, 751 05 Uppsala, Sweden.
Abstract
Gammaretrovirus-like sequences occur in most vertebrate
genomes.
Murine Leukemia Virus (MLV) like retroviruses (MLLVs) are
a subset, which may be pathogenic and spread
cross-species.
Retroviruses highly similar to MLLVs (xenotropic murine
retrovirus related virus (XMRV) and Human Mouse
retrovirus-like RetroViruses (HMRVs)) reported from patients
suffering from prostate cancer (PC) and myalgic
encephalomyelitis/chronic fatigue syndrome (ME/CFS)
raise the possibility that also humans have been infected.
Structurally intact, potentially infectious MLLVs occur in the
genomes of some mammals, especially mouse.
Mouse MLLVs contain three major groups.
One, MERV G3, contained MLVs and XMRV/HMRV.
Its presence in mouse DNA, and the abundance of
xenotropic MLVs in biologicals, is a source of false
positivity.
Theoretically, XMRV/HMRV could be one of several MLLV
transspecies infections.
MLLV pathobiology and diversity indicate optimal strategies
for investigating XMRV/HMRV in humans and raise ethical
concerns.
The alternatives that XMRV/HMRV may give a hard-to-detect
"stealth" infection, or that XMRV/HMRV never reached
humans, have to be considered.
PMID: 22315600 [PubMed - in process]
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