on toxin exposure in GWI patients which was followed by a sharp
exchange with Dr. Simon Wessely and colleagues. The paper and replies
are in the order below:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2393741/?tool=3Dpubmed
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359790/?tool=3Dpubmed
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587534/
Oxidative Stress and Mitochondrial Injury in Chronic Multisymptom
Conditions: From Gulf War Illness to Autism Spectrum Disorder
Beatrice A. Golomb1
Abstract:
Background: Overlapping chronic multisymptom illnesses (CMI) include
Chronic Fatigue Syndrome (CFS), fibromyalgia, irritable bowel
syndrome, multiple chemical sensitivity, and Gulf War illness (GWI),
and subsets of autism spectrum disorder (ASD). GWI entails a more
circumscribed set of experiences that may provide insights of
relevance to overlapping conditions.
Objectives: To consolidate evidence regarding a role for oxidative
stress and mitochondrial dysfunction (OSMD), as primary mediators in
CMI, using GWI as a departure point.
Methods: Exposure relations, character, timecourse and multiplicity of
symptoms, and objective correlates of GWI are compared to expectation
for OSMD. Objective correlates of OSMD in GWI and overlapping
conditions are examined.
Discussion: OSMD is an expected consequence of known GWI exposures; is
compatible with symptom characteristics observed; and accords with
objective markers and health conditions linked to GWI, extending to
autoimmune disease and infection. Emergent triangulating evidence
directly supports OSMD in multisymptom =93overlap=94 CMI conditions, with
similarities to, and diagnosed at elevated rates in, GWI, suggesting a
common role in each.
Conclusions: GWI is compatible with a paradigm by which uncompensated
exposure to oxidative/nitrative stressors accompanies and triggers
mitochondrial dysfunction, cell energy compromise, and multiple
downstream effects such as vulnerability to autoantibodies. This
promotes a profile of protean symptoms with variable latency
emphasizing but not confined to energy-demanding post-mitotic tissues,
according with (and accounting for) known properties of multisystem
overlap conditions.
This advances understanding of GWI; health conditions attending GWI at
elevated rates; and overlap conditions like CFS and ASD, providing
prospects for vulnerability assessment, mitigation of progression,
treatment, and future prevention =96 with implications germane to
additive and excessive environmental oxidative stressor exposures in
the civilian setting.
http://precedings.nature.com/documents/6847/version/1/files/npre20126847-1.=
pdf
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