IC=Interstitial Cystitis
PBS=Painful Bladder Syndrome
From: http://projectreporter.nih.gov/project_info_description.cfm
Project Number: 5U01DK082325-02
Sub-Project ID: 0002
Title: IC/PBS PHENOTYPES IN A COMMUNITY SAMPLE OF FEMALE TWINS
Principal Investigator (PI): BUCHWALD, DEDRA S
Organization: UNIVERSITY OF WASHINGTON
Abstract Text:
This study is positioned to identify and characterize the pathological and
physiological factors associated with IC/PBS and their relationship with
RCPS. It offers a novel opportunity to examine the genetic and common
environmental contributions to IC/PBS phenotypes. Our multidisciplinary
approach will expand knowledge of the underlying genetic, environmental, and
neurobiological factors that promote IC/PBS and its primary symptom of pain.
One major strength of this project is that it addresses all 3 MAPP RFA
Research Priorities. Our primary objective is to comprehensively investigate
UCPPS disease phenotypes. As we examine the demographic characteristics,
IC/PBS symptoms, clinical features (e.g., symptoms of FM, IBS, and CFS),
psychiatric symptoms, and psychosocial and functional status in Stage 1, we
also will address the epidemiology of IC/PBS. In Stage 2 we conduct a deep
phenotyping investigation of the IC/PBS physical/anatomical and
physiological characteristics. An important aspect of these studies is the
identification and characterization of pathological and physiological
associations between IC/PBS and related RCPS, such as FM and CFS. Stage 2's
emphasis on pathophysiology in a uniquely valuable small cohort,
incorporates a basic/translational science component. Specifically, we will
collect specimens to examine neural upregulation manifested as urothelial
dysfunction for Project 3 (an organ-system approach) to complement our
assessment of central sensitization and the HPA axis changes (a systemic
approach).
Project Terms:
No Project Terms available.
Other Information:
RFA/PA:
Study Section: ZDK1 Project Start Date: Project End Date:
Fiscal Year: 2009 Budget Start Date: 1-JUL-2009 Budget End Date: 30-JUN-2010
Administering Institutes or Centers: NATIONAL INSTITUTE OF DIABETES AND
DIGESTIVE AND KIDNEY DISEASES
Project Funding Information for 2009: Total Funding: $257,264
Year Funding IC FY Total Cost by IC
2009 NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$257,264
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