Monday, November 16, 2009

NOT: Immunobiology 5th edition by Janeway (online book)

This looks really sweet. It's 'Immunobiology' by Janeway available
online, it looks like a good place to get good information on
immunology-related subjects. The table of contents doesn't directly
link to the chapters, but by searching they are available, here they
are in order.

'Immunobiology' 5th edition by Charles Janeway, Paul Travers, Mark
Walport, Mark Schlomchik
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm


Book Information
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=imm_book_info

Preface to the Fifth Edition-
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A5

Acknowledgements-
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A6

Icons Used Throughout the Book
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=icons


Part I An Introduction to Immunobiology and Innate Immunity

Chapter 1- Basic Concepts in Immunology
-The components of the immune system
-Principles of innate and adaptive immunity
-The recognition and effector mechanisms of adaptive immunity
Summary to Chapter 1
General references
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A35

Chapter 2- Innate Immunity
-The front line of host defense
-The complement system and innate immunity
-Receptors of the innate immune system
-Induced innate responses to infection
Summary to Chapter 2
General references
Section references
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A148

Part II The Recognition of Antigen

Chapter 3- Antigen Recognition by B-cell and T-cell Receptors
-The structure of a typical antibody molecule
-The interaction of the antibody molecule with specific antigen
-Antigen recognition by T cells
Summary to Chapter 3
General references
Section references
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A322

Chapter 4- The Generation of Lymphocyte Antigen Receptors
-The generation of diversity in immunoglobulins
-T-cell receptor gene rearrangement
-Structural variation in immunoglobulin constant regions
Summary to Chapter 4
General references
Section references
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A435

Chapter 5- Antigen Presentation to T Lymphocytes
-The generation of T-cell receptor ligands
-The major histocompatibility complex and its functions
Summary to Chapter 5
General references
Section references
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A553

Part III The Development of Mature Lymphocyte Receptor Repertoires

Chapter 6- Signaling Through Immune System Receptors
-General principles of transmembrane signaling
-Antigen receptor structure and signaling pathways
-Other signaling pathways that contribute to lymphocyte behavior
Summary to Chapter 6
General references
Section references
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A673

Chapter 7- The Development and Survival of Lymphocytes
-Generation of lymphocytes in bone marrow and thymus
-The rearrangement of antigen-receptor gene segments controls
lymphocyte development
-Interaction with self antigens selects some lymphocytes for survival
but eliminates others
-Survival and maturation of lymphocytes in peripheral lymphoid tissues
Summary to Chapter 7
General references
Section references
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A797

Part IV The Adaptive Immune Response

Chapter 8- T Cell-Mediated Immunity
-The production of armed effector T cells
-General properties of armed effector T cells
-T cell-mediated cytotoxicity
-Macrophage activation by armed CD4 TH1 cells
Summary to Chapter 8
General references
Section references
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A1018

Chapter 9- The Humoral Immune Response
-B-cell activation by armed helper T cells
-The distribution and functions of immunoglobulin isotypes
-The destruction of antibody-coated pathogens via Fc receptors
Summary to Chapter 9
General references
Section references
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A1181

Chapter 10- Adaptive Immunity to Infection
-Infectious agents and how they cause disease
-The course of the adaptive response to infection
-The mucosal immune system
-Immunological memory
Summary to Chapter 10
General references
Section references
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A1322

Part V The Immune System in Health and Disease

Chapter 11- Failures of Host Defense Mechanisms
-Pathogens have evolved various means of evading or subverting normal
host defenses
-Inherited immunodeficiency diseases
-Acquired immune deficiency syndrome
Summary to Chapter 11
General references
Section references
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A1479

Chapter 12- Allergy and Hypersensitivity
-The production of IgE
-Effector mechanisms in allergic reactions
-Hypersensitivity diseases
Summary to Chapter 12
General references
Section references
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A1719

Chapter 13- Autoimmunity and Transplantation
-Autoimmune responses are directed against self antigens
-Responses to alloantigens and transplant rejection
-Self-tolerance and its loss
Summary to Chapter 13
General references
Section references
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A1905

Chapter 14- Manipulation of the Immune Response
-Extrinsic regulation of unwanted immune responses
-Using the immune response to attack tumors
-Manipulating the immune response to fight infection
Summary to Chapter 14
General references
Section references
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A2162

Chapter 15 Afterward: Evolution of the Immune System: Past, Present,
and Future, by Charles A. Janeway, Jr
-Evolution of the innate immune system
-Evolution of the adaptive immune response
-The importance of immunological memory in fixing adaptive immunity in
the genome
-Future directions of research in immunobiology
Summary of the Afterword
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=afterword

Appendices

Appendix I. Immunologists' Toolbox
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A2395

Appendix II. CD Antigens
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A2496

Appendix III. Cytokines and Their Receptors
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A2498

Appendix IV. Chemokines and Their Receptors
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A2500

Appendix V. Immunological Constants
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A2502

Biographies-
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=biographies

Glossary-
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm&part=A2528

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