By=A0Adrienne Dellwo, About.com Guide=A0=A0=A0February 2, 2012
Note: About.com writer Adrienne Dwello breaks down "Increased
ventricular lactate in chronic fatigue syndrome. III. Relationships to
cortical glutathione and clinical symptoms implicate oxidative stress
in disorder pathophysiology" which was posted on co-cure a week or so
ago and she includes treatment information targeting oxidative stress.
Research Brief
A=A0new study=A0supports the theory that=A0chronic fatigue syndrome(ME/CFS)
may be related to oxidative stress, and that oxidative stress may play
a key causative role in the illness.
This was the third study in a series looking at several possible
components of ME/CFS:
Ventricular lactate
Cortical glutathione
Oxidative stress
The earlier research had uncovered significantly elevated levels of
ventricular cerebrospinal-fluid lactate in ME/CFS, as compared to
generalized anxiety disorder and healthy controls. In this study,
researchers wanted to see if the high lactate levels could be caused
by increased oxidative stress, low blood flow to the brain, and/or
mitochondrial dysfunction (which involves the building blocks of
cells.)
They say results showed significantly high ventricular lactate in
participants with ME/CFS compared to healthy controls. They also
report an insignificant difference in measures of cortical glutathione
and no difference in markers of mitochondrial function.
In addition, ventricular lactate was highest and cortical glutathione
was lowest in the most severe cases.
Researchers concluded that this study supports the pathphysiological
model of ME/CFS with oxidative stress as a possible underlying cause.
Read the full article as well as a link to Dr. Martin Pall's protocol
here: http://chronicfatigue.about.com/b/2012/02/02/oxidative-stress-in-chro=
nic-fatigue-syndrome.htm
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