Permanent relief from intermittent cold stress-induced
fibromyalgia-like abnormal pain by repeated intrathecal administration
of antidepressants
Michiko Nishiyori, Hitoshi Uchida, Jun Nagai, Kohei Araki, Takehiro
Mukae, Shiroh Kishioka and Hiroshi Ueda
Molecular Pain 2011, 7:69 doi:10.1186/1744-8069-7-69
Published: 21 September 2011
Abstract (provisional)
Background
Fibromyalgia (FM) is characterized by chronic widespread pain, which
is often refractory to conventional painkillers. Numerous clinical
studies have demonstrated that antidepressants are effective in
treating FM pain. We previously established a mouse model of FM-like
pain, induced by intermittent cold stress (ICS).
Results
In this study, we find that ICS exposure causes a transient increase
in plasma corticosterone concentration, but not in anxiety or
depression-like behaviors. A single intrathecal injection of an
antidepressant, such as milnacipran, amitriptyline, mianserin or
paroxetine, had an acute analgesic effect on ICS-induced thermal
hyperalgesia at post-stress day 1 in a dose-dependent manner. In
addition, repeated daily antidepressant treatments during post-stress
days 1-5 gradually reversed the reduction in thermal pain threshold,
and this recovery was maintained for at least 7 days after the final
treatment. In addition, relief from mechanical allodynia, induced by
ICS exposure, was also observed at day 9 after the cessation of
antidepressant treatment. In contrast, the intravenous administration
of these antidepressants at conventional doses failed to provide
relief.
Conclusions
These results suggest that the repetitive intrathecal administration
of antidepressants permanently cures ICS-induced FM pain in mice.
http://www.molecularpain.com/content/7/1/69/abstract
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