Tuesday, September 20, 2011

RES: Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection

Note: This study reports that XMRV can infect neuronal cells, however
this research was done in petri dishes. XMRV has still not been
conclusively shown to infect any population, whether it be ME/CFS or
prostate cancer patients, or healthy controls.

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http://www.virologyj.com/content/8/1/443/abstract
fulltext- http://www.virologyj.com/content/pdf/1743-422X-8-443.pdf

Short report

Susceptibility of human primary neuronal cells to Xenotropic Murine
Leukemia Virus-related (XMRV) virus infection.
Veerasamy Ravichandran, Eugen O Major, Carol Ibe, Maria Chiara Monaco,
Mohan Kumar Haleyur Girisetty and Indira K Hewlett
Virology Journal 2011, 8:443 doi:10.1186/1743-422X-8-443

Published: 20 September 2011
Abstract (provisional)

Background
Xenotropic Murine Leukemia Virus-related (XMRV) virus is a recently
identified mouse gammaretrovirus that has the ability to infect
certain human cells. In this study, we investigated the susceptibility
of primary neuronal cell types to infection with XMRV. Findings: We
observed that the human primary progenitors, progenitor-derived
neurons, and progenitor-derived astrocytes supported XMRV
multiplication. Interestingly, both progenitors and progenitor-derived
neurons were more susceptible compared with progenitor-derived
astrocytes. In addition, XMRV-infected Jurkat cells were able to
transmit infection to neuronal cells.

Conclusions
These data suggest that neuronal cells are susceptible for XMRV infection.

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