fulltext- http://www.hindawi.com/journals/av/aip/403419.pdf
Review Article
Murine Leukemia Viruses: Biology and Replication
Alan Rein
ABSTRACT
Murine leukemia viruses (MLVs) are among the simplest retroviruses.
Prototypical gammaretroviruses, they encode only the three
polyproteins that will be used in the assembly of progeny virus
particles. These are the Gag polyprotein, which is the structural
protein of a retrovirus particle; the Pol protein, comprising the
three retroviral enzymes=97protease, which catalyzes the maturation of
the particle; reverse transcriptase, which copies the viral RNA into
DNA upon infection of a new host cell; and integrase, which inserts
the DNA into the chromosomal DNA of the host cell; and the Env
polyprotein, which induces the fusion of the viral membrane with that
of the new host cell, initiating infection. In general, a productive
MLV infection has no obvious effect upon host cells. Although
gammaretroviral structure and replication follow the same broad
outlines as those of other retroviruses, we point out a number of
significant differences between different retroviral genera.
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