study. The next step would be to get the same results in primates
ideally without severe side-effects. Only then could the hypothesis
be tested on human subjects. Kai Xin San (KXS), a traditional Chinese
herbal medicine, has been used clinically for the treatment of
depressive disorders and cognitive impairment for centuries.
J Ethnopharmacol. 2011 Aug 22. [Epub ahead of print]
Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic
fatigue syndrome mice induced by forced wheel running.
Cao Y, Hu Y, Liu P, Zhao HX, Zhou XJ, Wei YM.
Department of Clinical Pharmacology, Chinese PLA General Hospital,
Beijing 100853, China; Bengbu Medical College, Bengbu 233000, China.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE:
In traditional medicine, Kai Xin San (KXS), composed of ginseng (Panax
ginseng), hoelen (Wolfiporia cocos), polygala (Polygala tenuifolia)
and Acorus gramineus, is famous for the treatment of emotion-thought
disease, such as settling fright, quieting the spirit and nourishing
the heart.
AIM OF THE STUDY:
The present study investigated the effect of KXS on chronic fatigue
syndrome (CFS) mice induced by forced wheel running.
MATERIALS AND METHODS:
Seventy two healthy adult male Kunming mice were randomly divided into
six groups: home cage control group, CFS group, CFS group with
Modafinil treatment at 13mg/kg/d doge, KXS treatment at 175mg/kg/d,
350mg/kg/d and 700mg/kg/d doge. CFS mice were induced by forced wheel
running with higher speed for 4 weeks and then taken an exhausted
exercise. The biochemical parameters including serum lactate
dehydrogenase (LDH), serum urea nitrogen (SUN), serum testosterone
(T), liver glycogen (LG), muscle glycogen (MG) and muscle lactic acid
(MLA) were determined by using commercially available kits. The
splenocytes proliferation from mice was examined by MTT method. The
levels of interleukin-2 (IL-2) and interleukin-4 (IL-4) secreted by
splenocytes were determined by ELISA.
RESULTS:
CFS mice with KXS administration exhibited less electric shock time
when compared with CFS group without drug treatment. The effect of KXS
has after demonstrated reduction in SUN, LDH and MLA levels and an
increase in T, LG and MG levels. CFS mice with KXS could improve the
proliferation of splenocytes compared with CFS group without drug
treatment. The cultured splenocytes from CFS mice without KXS
supplementation produced more interleukin-2 (IL-2) but less
interleukin-4 (IL-4) when compared with home cage control mice. The
cultured splenocytes of CFS mice with KXS supplementation produced
more interleukin-2 (IL-2) but less interleukin-4 (IL-4) when compared
with CFS group without drug treatment.
CONCLUSIONS:
The results of this preliminary study provide evidence that KXS could
ameliorate CFS by affecting the physiological markers for fatigue.
This study also supported the use of KXS against CFS by improving the
proliferation of splenocytes from CFS mice and modulating the
disturbance of cytokines induced by CFS.
Copyright =A9 2011. Published by Elsevier Ireland Ltd.
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