triggered by exposure to different kinds of environmental stress
conditions, such as infection, inflammation, exercise, exposure of the
cell to toxins (ethanol, arsenic, trace metals and ultraviolet light,
among many others), starvation, hypoxia (oxygen deprivation), or water
deprivation. Consequently, the heat shock proteins are also referred
to as stress proteins and their upregulation is sometimes described
more generally as part of the stress response.
Heat shock proteins appear to serve a significant cardiovascular and
immunological role. Extracellular and membrane bound heat-shock
proteins, especially Hsp70 are involved in binding antigens and
presenting them to the immune system.
The abstract does not say which definition was used in diagnosing CFS
J Intern Med. 2011 Nov 24. doi: 10.1111/j.1365-2796.2011.02488.x.
[Epub ahead of print]
Chronic fatigue syndrome: acute infection and history of physical
activity affect resting levels and response to exercise of plasma
oxidant/antioxidant status and heat shock proteins.
Jammes Y, Steinberg JG, Delliaux S.
UMR MD2 P2COE, Faculty of Medicine, Aix-Marseille University and
Clinical Respiratory Physiology and Exercise Testing Laboratory,
Thorax Pole, National Assistance - Hospitals in Marseille, 13915
Marseille, France.
Abstract
Objectives:=E2=80=82 A history of high-level physical activity and/or acute
infection might constitute stress factors affecting the plasma
oxidant-antioxidant status and levels of heat shock proteins (HSPs) in
patients with chronic fatigue syndrome (CFS).
Design:=E2=80=82 This case-control study compared data from 43 CFS patients=
to
results from a matched control group of 23 healthy sedentary subjects.
Setting and subjects:=E2=80=82 Five patients had no relevant previous histo=
ry
(group I). Eighteen had practised high-level sport (group II) and
severe acute infection had been diagnosed in nine patients (group
III). A combination of sport practice and infection was noted in 11
patients (group IV).
Interventions:=E2=80=82 After examination at rest, all subjects performed a
maximal cycling exercise test. Plasma levels of two markers of
oxidative stress [thiobarbituric acid reactive substances (TBARS) and
reduced ascorbic acid (RAA)] and both HSP27 and HSP70 were measured.
Results:=E2=80=82 At rest, compared to the control group, the TBARS level w=
as
higher in groups II, III and IV patients, and the RAA level was lower
in groups III and IV.
In addition, HSP70 levels were significantly lower in all CFS groups,
compared with controls, but negative correlations were found between
resting HSP27 and HSP70 levels and the history of physical activity.
After exercise, the peak level of TBARS significantly increased in
groups II, III and IV, and the variations in HSP27 and HSP70 were
attenuated or suppressed, with the greatest effects in groups III and
IV.
Conclusion:=E2=80=82 The presence of stress factors (infection and high lev=
el
physical activity) in the history of CFS patients is associated with
severe oxidative stress and the suppression of protective HSP27 and
HSP70 responses to exercise.
Copyright =C2=A9 2011 The Association for the Publication of the Journal of
Internal Medicine.
PMID: 22112145 [PubMed - as supplied by publisher]
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