Transfusion. 2011 Nov 21. doi: 10.1111/j.1537-2995.2011.03450.x. [Epub
ahead of print]
Xenotropic murine leukemia virus-related virus does not pose a risk to
blood recipient safety.
Dodd RY, Hackett Jr J, Linnen JM, Dorsey K, Wu Y, Zou S, Qiu X,
Swanson P, Schochetman G, Gao K, Carrick JM, Krysztof DE, Stramer SL.
SourceFrom the American Red Cross Holland Laboratory, Rockville,
Maryland; Abbott Diagnostics, Abbott Park, Illinois; Gen-Probe, Inc.,
San Diego, California; the Yale University School of Medicine, New
Haven, Connecticut; and the American Red Cross Scientific Support
Office, Gaithersburg, Maryland.
Abstract
BACKGROUND: When xenotropic murine leukemia virus-related virus (XMRV)
was first reported in association with chronic fatigue syndrome, it
was suggested that it might offer a risk to blood safety. Thus, the
prevalence of the virus among blood donors and, if present, its
transmissibility by transfusion need to be defined.
STUDY DESIGN AND METHODS: Two populations of routine blood donor
samples (1435 and 13,399) were obtained for prevalence evaluations;
samples from a linked donor-recipient repository were also evaluated.
Samples were tested for the presence of antibodies to XMRV-related
recombinant antigens and/or for XMRV RNA, using validated,
high-throughput systems.
RESULTS: The presence of antibodies to XMRV could not be confirmed
among a total of 17,249 blood donors or recipients (0%; 95% confidence
interval [CI], 0%-0.017%); 1763 tested samples were nonreactive for
XMRV RNA (0%; 95% CI, 0%-0.17%). Evidence of infection was absent from
109 recipients and 830 evaluable blood samples tested after
transfusion of a total of 3741 blood components.
CONCLUSIONS: XMRV and related murine leukemia virus (MLV) markers are
not present among a large population of blood donors and evidence of
transfusion transmission could not be detected. Thus, these viruses do
not currently pose a threat to blood recipient safety and further
actions relating to XMRV and MLV are not justified.
=A9 2011 American Association of Blood Banks.
PMID:22098340[PubMed - as supplied by publisher]
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