Send an Email for free membership
~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~
>>>>> Help ME Circle <<<<
>>>> 29 November 2011 <<<<
Editorship : j.van.roijen@chello.nl
~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~
http://www.ncbi.nlm.nih.gov/pubmed/22120591
Clin Cardiol. 2011 Nov 28. doi: 10.1002/clc.20962.
Small Heart With Low Cardiac Output for
Orthostatic Intolerance in Patients With
Chronic Fatigue Syndrome.
Miwa K, Fujita M.
Source
Department of Internal Medicine, Miwa Naika Clinic,
Toyama. info@miwa-naika.com.
Abstract
BACKGROUND:
The etiology of chronic fatigue syndrome (CFS) is
unknown. Orthostatic intolerance (OI) is common in
CFS patients. Recently, small heart with low cardiac
output has been postulated to be related to the genesis
of both CFS and OI.
HYPOTHESIS:
Small heart is associated with OI in patients with CFS.
METHODS:
Study CFS patients were divided into groups of 26
(57%) CFSOI(+) and 20 (43%) CFSOI(-) according
to the presence or absence of OI. In addition, 11 OI
patients and 27 age- and sex-matched control subjects
were studied. Left ventricular (LV) dimensions and
function were determined echocardiographically.
RESULTS:
The mean values of cardiothoracic ratio, systemic
systolic and diastolic pressures, LV end-diastolic
dimension, LV end-systolic dimension, stroke volume
index, cardiac index, and LV mass index were all
significantly smaller in CFSOI(+) patients than in
CFSOI(-) patients and healthy controls, and also in OI
patients than in controls. A smaller LV end-diastolic
dimension (<40 mm) was significantly (P<0.05) more
prevalently noted in CFSOI(+) (54%) and OI (45%)
than in CFSOI(-) (5%) and controls (4%). A lower
cardiac index (<2 L/min/mm(2) ) was more prevalent
in CFSOI(+) (65%) than in CFSOI(-) (5%, P<0.01),
OI (27%), and controls (11%, P<0.01).
CONCLUSIONS:
A small size of LV with low cardiac output was noted in
OI, and its degree was more pronounced in
CFSOI(+). A small heart appears to be related to the
genesis of OI and CFS via both cerebral and systemic
hypoperfusion. CFSOI(+) seems to constitute a
well-defined and predominant subgroup of CFS.
=A9 2011 Wiley Periodicals, Inc. The authors have no
funding, financial relationships, or conflicts of interest
to disclose.
=A9 2011 Wiley Periodicals, Inc.
PMID: 22120591 [PubMed - as supplied by publisher]
~~~~=20
---------------------------------------------
Send posts to CO-CURE@listserv.nodak.edu
Unsubscribe at http://www.co-cure.org/unsub.htm
Co-Cure Archives: http://listserv.nodak.edu/archives/co-cure.html
---------------------------------------------
Co-Cure's purpose is to provide information from across the spectrum of
opinion concerning medical, research and political aspects of ME/CFS and/or
FMS. We take no position on the validity of any specific scientific or
political opinion expressed in Co-Cure posts, and we urge readers to
research the various opinions available before assuming any one
interpretation is definitive. The Co-Cure website <www.co-cure.org> has a
link to our complete archive of posts as well as articles of central
importance to the issues of our community.
---------------------------------------------
