two CFS studies including one on XMRV, recently spoke at the
Whittemore Peterson Institute. Dr. Lipkin has also done viral research
on CFS in the past.
The full webcast of his presentation can be found here:
http://imedia.unr.edu/unsom/whittemore_peterson_institute/dr_ian_lipkin.htm=
l
Previous research:
J Neurovirol. 1999 Oct;5(5):495-9.
Absence of evidence of Borna disease virus infection in Swedish
patients with Chronic Fatigue Syndrome.
Eveng=E5rd B, Briese T, Lindh G, Lee S, Lipkin WI.
Department of Immunology, Microbiology, Pathology and Infectious
Diseases, Clinic for Infectious Diseases, Karolinska Institutet at
Huddinge University Hospital.
Abstract
Chronic Fatigue Syndrome (CFS) is characterized by debilitating
fatigue, somatic symptoms and cognitive impairment. An infectious
basis has been proposed; candidate agents include enteroviruses,
herpesviruses, retroviruses and Borna disease virus (BDV), a novel
neurotropic virus associated with neuropsychiatric disorders.
Sera and peripheral blood mononuclear cells (PBMC) from Swedish CFS
patients were assayed for evidence of infection using ELISA and
Western immunoblot for detection of antibodies to BDV proteins N, P
and gp18; and using nested reverse transcriptase polymerase chain
reaction (RT-PCR) for detection of BDV N- and P-gene transcripts.
No specific immunoreactivity to BDV proteins was found in sera from
169 patients or 62 controls. No BDV N- or P-gene transcripts were
found through RT-PCR analysis of PBMC from 18 patients with severe
CFS. These results do not support a role for BDV in pathogenesis of
CFS.
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