Epigallocatechin gallate ameliorates behavioral and biochemical deficits =
in rat model of load-induced chronic fatigue syndrome.
Sachdeva AK, Kuhad A, Chopra K.
Source
Pharmacology Research Laboratory, University Institute of Pharmaceutical =
Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh 160=
014, India.
Abstract
Chronic fatigue syndrome is a heterogeneous disorder with unknown pathoge=
nesis and etiology, characterized by tiredness, difficulty in concentrati=
on and memory, and concomitant skeletal and muscular pain, thus affecting=
both mental and physical domains. The pathogenesis of chronic fatigue sy=
ndrome is multifactorial and involves increased oxido-nitrosative stress =
along with generation of pro-inflammatory cytokines such as TNF-=CE=B1. I=
n the present study chronic fatigue was produced in rats by plunging a lo=
ad of 10=C2=B12% body weight and subjecting them to forced swim inside a =
rectangular jar daily for 28 days. Endurance capacity and post-swim fatig=
ue were assessed on 1st, 7th, 14th, 21st and 28th days. EGCG was administ=
ered daily by oral gavage 30min before forced swim session. On the 29th d=
ay, after assessment of various behavioral parameters, blood was collecte=
d through tail vein, and animals were sacrificed to harvest the brains, s=
pleens and thymus. Chronic fatigue group exhibited significant behavioral=
alterations along with enhanced oxido-nitrosative stress and serum TNF-=CE=
=B1 level as compared to naive group. Chronic treatment with EGCG restore=
d all the behavioral and biochemical alterations associated with chronic =
fatigue syndrome. The present study signifies the therapeutic potential o=
f EGCG for the treatment of chronic fatigue syndrome.
Copyright =C2=A9 2011 Elsevier Inc. All rights reserved.
PMID:=20
21821105=20
[PubMed - as supplied by publisher]=20
http://www.ncbi.nlm.nih.gov/pubmed/21821105 =20
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