disappointing to patients and scientists alike, there is no evidence
that a global conspiracy to deny XMRV exists - it is just how science
works. The science process itself, regardless of the disease or
pathogen, can be controversial and contentious as scientists study the
complex variables and put forth differing hypotheses - it is just how
science works.
Cancer Epidemiol Biomarkers Prev. 2011 Aug 22. [Epub ahead of print]
The retrovirus XMRV is not directly involved in the pathogenesis of
common types of lymphoid malignancy.
Waugh EM, Jarrett RF, Shield L, Montgomery D, Dean RT, Mitchell A,
Greaves MF, Gallagher A.
1Institute of Infection, Immunity and Inflammation, University of Glasgow.
Abstract
BACKGROUND:
A novel retrovirus, xenotropic murine leukaemia virus-related virus
(XMRV), has been detected in prostate cancer samples and in peripheral
blood mononuclear cells (PBMCs) from patients with chronic fatigue
syndrome (CFS). In addition, the virus has been identified in PBMCs
from healthy controls. These data suggest that XMRV is circulating in
the human population. XMRV is closely related to murine leukaemia
viruses, which cause lymphoid malignancies in mice. The aim of the
current study was to determine whether XMRV is directly associated
with common forms of human lymphoma or leukaemia.
METHODS:
DNA samples from 368 patients with lymphoid malignancies and 139
patients with benign lymphadenopathy or other malignant disease were
screened for XMRV using three specific and sensitive, quantitative PCR
assays.
RESULTS:
XMRV was not detected in any sample using any of the three assays.
CONCLUSION:
The data suggest that this virus is not directly involved in the
pathogenesis of common types of lymphoid malignancy, and that XMRV is
not a prevalent blood borne infection, at least in the UK. Impact:
There is no evidence XMRV is associated with lymphoid malignancies,
and further studies should resolve inconsistencies in results of
studies examining XMRV prevalence.
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