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>>>>> Help ME Circle <<<<
>>>> 28 August 2011 <<<<
Editorship : j.van.roijen@chello.nl
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PubMed
US National Library of Medicine
National Institutes of Health
AJNR Am J Neuroradiol. 2011 Aug 25.
[Epub ahead of print]
Cerebral Blood Flow Alterations in
Pain-Processing Regions of Patients
with Fibromyalgia Using Perfusion MR
Imaging
Foerster BR, Petrou M, Harris RE, Barker PB,
Hoeffner EG, Clauw DJ, Sundgren PC.
Division of Neuroradiology, Department of
Radiology, and Departments of Anesthesiology,
Psychiatry, and Internal Medicine, Division of
Rheumatology, University of Michigan, Ann Arbor,
Michigan; Russell H. Morgan Department of
Radiology and Radiological Science, Johns
Hopkins University School of Medicine, Baltimore,
Maryland; VA Ann Arbor Healthcare System, Ann
Arbor, Michigan; and Department of Diagnostic
Radiology, Clinical Sciences Lund, Lund
University, Lund, Sweden.
Abstract
BACKGROUND AND PURPOSE:
Widespread pain sensitivity in patients with FM
suggests a CNS processing problem.
The purpose of this study was to assess alterations
in perfusion as measured by DSC in a number of
brain regions implicated in pain processing
between patients with FM and healthy controls.
MATERIALS AND METHODS:
Twenty-one patients with FM and 27 healthy
controls underwent conventional MR imaging and
DSC.
For DSC, 12 regions of interest were placed in brain
regions previously implicated in pain processing.
rCBF values were calculated for each region of
interest.
Subjects answered mood/pain coping
questionnaires and underwent clinical/experimental
pain assessment.
RESULTS:
There were significant correlations between the
thalamic rCBF values and the pain-control beliefs of
FM subjects.
The strength of the relationship between clinical
pain measures and thalamic rCBF values
increased after adjusting for pain-control beliefs.
There was a significantly different distribution
pattern of rCBF values across various brain regions
between the FM group and the healthy controls.
There was a lower degree of correlation in the FM
group between the thalamic rCBF values and the
other brain regions relative to the healthy controls.
CONCLUSIONS:
Significant correlations were found between
thalamic rCBF values and pain belief values.
These data suggest that there are baseline
alterations of brain perfusion in patients with FM.
rCBF values of the thalami exhibited lower
correlations with respect to other brain regions
thought to be involved in pain processing compared
with those in healthy controls.
PMID: 21868622 [PubMed - as supplied by
publisher]
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