http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027391
Absence of Detectable XMRV and Other MLV-Related Viruses in Healthy
Blood Donors in the United States
Shixing Tang*, Jiangqin Zhao, Mohan Kumar Haleyur Giri Setty,
Krishnakumar Devadas, Durga Gaddam, Ragupathy Viswanath, Owen Wood,
Panhe Zhang, Indira K. Hewlett*
Lab of Molecular Virology, Center for Biologics Evaluation and
Research, Food and Drug Administration, Bethesda, Maryland, United
States of America
Abstract
Background
Preliminary studies in chronic fatigue syndrome (CFS) patients and
XMRV infected animals demonstrated plasma viremia and infection of
blood cells with XMRV, indicating the potential risk for transfusion
transmission. XMRV and MLV-related virus gene sequences have also been
detected in 4=966% of healthy individuals including blood donors in the
U.S. These results imply that millions of persons in the U.S. may be
carrying the nucleic acid sequences of XMRV and/or MLV-related
viruses, which is a serious public health and blood safety concern.
Methodology/Principal Findings
To gain evidence of XMRV or MLV-related virus infection in the U.S.
blood donors, 110 plasma samples and 71 PBMC samples from blood donors
at the NIH blood bank were screened for XMRV and MLV-related virus
infection. We employed highly sensitive assays, including nested PCR
and real-time PCR, as well as co-culture of plasma with highly
sensitive indicator DERSE cells. Using these assays, none of the
samples were positive for XMRV or MLV-related virus.
Conclusions/Significance
Our results are consistent with those from several other studies, and
demonstrate the absence of XMRV or MLV-related viruses in the U.S.
blood donors that we studied.
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