Sleep. 2011 Nov 1;34(11):1551-60.
Sleep-Stage Dynamics in Patients with Chronic Fatigue Syndrome with or
without Fibromyalgia.
Kishi A, Natelson BH, Togo F, Struzik ZR, Rapoport DM, Yamamoto Y.
Abstract
STUDY OBJECTIVES: Chronic fatigue syndrome (CFS) and fibromyalgia (FM)
are medically unexplained conditions that often have overlapping
symptoms, including sleep-related complaints. However, differences
between the 2 conditions have been reported, and we hypothesized that
dynamic aspects of sleep would be different in the 2 groups of
patients.
PARTICIPANTS: Subjects were 26 healthy control subjects, 14 patients
with CFS but without FM (CFS alone), and 12 patients with CFS and FM
(CFS+FM)-all women.
MEASUREMENTS AND RESULTS: We studied transition probabilities and
rates between sleep stages (waking, rapid eye movement [REM] sleep,
stage 1 [S1], stage 2 [S2], and slow-wave sleep [SWS]) and duration
distributions of each sleep stage. We found that the probability of
transition from REM sleep to waking was significantly greater in
subjects with CFS alone than in control subjects, which may be the
specific sleep problem for people with CFS alone. Probabilities of (a)
transitions from waking, REM sleep, and S1 to S2 and (b) those from
SWS to waking and S1 were significantly greater in subjects with
CFS+FM than in control subjects; in addition, rates of these
transitions were also significantly increased in subjects with CFS+FM.
Result (a) might indicate increased sleep pressure in subjects with
CFS+FM whereas result (b) may be the specific sleep problem of
subjects with CFS+FM. We also found that shorter durations of S2 sleep
are specific to patients with CFS+FM, not to CFS alone.
CONCLUSIONS: These results suggest that CFS and FM may be different
illnesses associated with different problems of sleep regulation.
CITATION: Kishi A; Natelson BH; Togo F; Struzik ZR; Rapoport DM;
Yamamoto Y. Sleep-stage dynamics in patients with chronic fatigue
syndrome with or without fibromyalgia. SLEEP 2011;34(11):1551-1560.
PMID:22043126[PubMed - in process]
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