well as standardizing testing materials across labs - something the US
Blood Safety group and the scientists involved in Dr. Ian Lipkin's
current XMRV are also looking at.
Advances in Virology
Volume 2011 (2011), Article ID 281425, 5 pages
doi:10.1155/2011/281425
Review Article
Testing Strategies for Detection of Xenotropic Murine Leukemia
Virus-Related Virus Infection
Shixing Tang and Indira K. Hewlett
Laboratory of Molecular Virology, CBER, Food and Drug Administration,
Bethesda, MD 20892, USA
Received 10 March 2011; Revised 18 May 2011; Accepted 10 June 2011
Academic Editor: Myra McClure
Copyright =A9 2011 Shixing Tang and Indira K. Hewlett. This is an open
access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly
cited.
Abstract
Xenotropic murine leukemia virus-related virus (XMRV) is a newly
identified gamma retrovirus and may be associated with prostate
cancer- (PC) and chronic fatigue syndrome (CFS). Since its
identification in 2006 and detection of polytropic murine lenkemia
virus (MLV)-like sequences in CFS patients in 2010, several test
methods including nucleic acid testing methods and serological assays
have been developed for detection of XMRV and/or MLV-like sequences.
However, these research assays have not yet been validated and
evaluated due to the lack of well-characterized reference materials.
Mouse DNA contamination should be carefully checked when testing human
specimens in order to avoid false-positive detection of XMRV or
MLV-like sequences.
http://www.hindawi.com/journals/av/2011/281425/
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